England snapped up three late wickets to leave Pakistan 183 for six at the close on the fourth day of the second Test on Wednesday, an overall lead of 199 runs.
Andrew Flintoff removed Mohammad Yousuf (20) and Shahid Afridi (0) in successive balls before Steve Harmison dismissed Kamran Akmal for nine.
Captain Inzamam-ul Haq was 41 not out when play ended 16 overs early due to bad light.
Flintoff's spell of two wickets for 15 runs from seven overs after tea has given England an outside chance of an upset win.
Pakistan lead the three-match series after winning the first Test in Multan by 22 runs.
Flintoff ended a fourth-wicket stand of 56 with Inzamam when he forced Yousuf to play on to his stumps.
He than silenced the roaring capacity crowd with a fantastic ball that pitched in sharply to send Afridi's off-stump cartwheeling.
Afridi had provided much of the entertainment in the first innings with a blistering knock of 92 from 85 balls and after his first-ball dismissal the majority of the crowd left the stadium.
Harmison then had Akmal caught behind in the final over of the day as Pakistan lost their last five wickets for 79 runs.
STOOD FIRM
Flintoff also caused the usually solid Inzamam considerable discomfort and had a confident leg before shout against him turned down by umpire Simon Taufel.
Inzamam stood firm and steadied the ship with another patient innings spanning 70 balls, nine runs short of his fourth half-century in the series following scores of 53, 72 and 109.
The Pakistan innings fell away after another solid opening start of 54 by Salman Butt (50) and Shoaib Malik (26).
Butt was out one ball after having a run disallowed by umpire Darrell Hair who warned him a second time for running on to the pitch.
The opener played Shaun Udal into the off-side and set off for a single but on reaching the other end saw Hair signalling a dead ball and asking him to go back.
Udal trapped Butt leg before next ball, bowling round the wicket.
Malik was the first wicket to fall after Pakistan resumed on 50 following lunch. He played a careless looking drive to cover where Ian Bell caught him off Flintoff.
Younis Khan (27) was the next man out, given lbw to Matthew Hoggard.
Pakistan had bowled out England out for 446 in the first hour of the morning session just 16 runs short of their total of 462.
England, resuming on 391 for seven, quickly lost Ashley Giles and Hoggard to Afridi, who finished with four wickets for 95 runs.
Udal and Harmison (16) swung the bat lustily to add a valuable 47 runs from 37 balls for the last wicket.
Udal hit three fours and one six in his unbeaten 33 and took 16 runs in one over from Shoaib Akhtar.
Scorecard
Pakistan (1st innings): 462 (Inzamam-ul Haq 109, S. Afridi 92, M. Yousuf 78)
England (1st innings): (Overnight: 391-7)
M. Trescothick c Akmal b Sami 48
A. Strauss b Naved-ul-Hasan 12
M. Vaughan b Naved-ul-Hasan 2
I. Bell c Akmal b Afridi 115
K. Pietersen c Yousuf b Akhtar 100
A. Flintoff b Akhtar 1
G. Jones lbw b Afridi 55
A. Giles b Afridi 26
S. Udal not out 33
M. Hoggard b Afridi 2
S. Harmison run out 16
Extras: (b-1, lb-12, nb-22, w-1) 36
Total: (all out, 132.3 overs) 446
Fall of wickets: 1-33, 2-39, 3-107, 4-261, 5-272, 6-327, 7-378, 8-395, 9-399, 10-446.
Bowling: S. Akhtar 27-4-93-2 (nb-4, w-1), Naved-ul-Hasan 20-2-63-2 (nb-8), M. Sami 19-4-51-1, S. Afridi 30.3-3-95-4 (nb-7), D. Kaneria 32-3-102-0 (nb-3), S. Malik 4-0-29-0.
Pakistan (2nd innings):
S. Malik c Bell b Flintoff 26
S. Butt lbw b Udal 50
Y. Khan lbw b Hoggard 27
M. Yousuf b Flintoff 20
Inzamam-ul-Haq not out 41
S. Afridi b Flintoff 0
K. Akmal c G. Jones b Harmison 9
Naved-ul-Hasan not out 0
Extras: (b-4, lb-4, nb-2) 10
Total: (for 6 wickets, 66 overs) 183
Fall of wickets: 1-54, 2-104, 3-108, 4-164, 5-164, 6-183
To bat: S. Akhtar, M. Sami, D. Kaneria
Bowling: M. Hoggard 9-0-28-1, A. Flintoff 19-2-46-3 (nb-2), S. Harmison 14-2-41-1, A. Giles 13-2-35-0, S. Udal 11-2-25-1.
