England fast bowler Steve Harmison will miss the one-day series starting next week against Pakistan through injury, the ECB said on Monday.
The England and Wales Cricket Board said in a statement that Harmison's absence is a "precautionary measure" after his sore lower back failed to respond to treatment.
A replacement has not been called up yet but Harmison's absence gives extended opportunities to the likes of Stuart Broad, Sajid Mahmood and veteran Darren Gough.
England's chances of success in the five-match one-day series that begins in Cardiff on Wednesday already appeared slim following their 5-0 defeat to Sri Lanka in June.
The news on Harmison was announced after England suffered their eighth straight limited-overs defeat with a five-wicket loss to Pakistan in a Twenty20 international.
ALL DEPARTMENTS
Marcus Trescothick, England's top-scorer in Monday's clash at Bristol (53 from 36 balls), said the team needs to strengthen in all departments to improve their one-day struggles.
Following comprehensive one-day series defeats in Pakistan and then India, England lost the Twenty20 international after defeats in all five 50-over matches against Sri Lanka.
On Monday, England managed just 144-7 from their 20 overs, which was 24 runs below the average first innings Twenty20 total at the Bristol ground.
With the team's most influential player, Andrew Flintoff, still injured, and Harmison having joined the casualty list England know they have a lot of work to do.
"All areas need to improve," Trescothick said. "Our batting has to improve, our bowling has to improve and our fielding has to improve.
"In all areas we need to raise our game by 10 or 15 percent. In our batting we need to make bigger scores, bowlers need to get more wickets, which is an obvious thing for me to say, and we have to take more catches."
Trescothick said the loss of four quick wickets was the reason for Monday's loss as they slumped from 39-0 to 50-4 while the tourists put last week's fourth Test troubles behind them.
