The England and Wales Cricket Board (ECB) said in a statement that the 30-year-old batsman had been omitted from their squads for the Twenty20 [ Images ] internationals against Pakistan which start on Sunday and the five one-dayers that follow.
Pietersen, part of the Twenty20 World Cup-winning side earlier this year and player of that tournament, wrote briefly on his Twitter account that he was "Done for rest of summer. Man of the World Cup T20 and dropped from the T20 side too."
The 30-year-old batsman added he had been signed by county club Surrey after leaving Hampshire.
The Twitter message was quickly deleted, with England due to announce later in the day their squads for the Twenty20 internationals against Pakistan which start on Sunday and the five one-dayers that follow.
A spokesman for the England and Wales Cricket Board (ECB) was not immediately available. A Surrey spokesman had no comment.
If confirmed, it would be the first time Pietersen has been dropped since the South African-born player's England career started in 2004.
Pietersen's recent form has dipped and a break from international play would give him time to get more first class cricket under his belt before the start of the Ashes in Australia [ Images ] in November.
Twenty20 squad: Collingwood, Anderson, Bopara, Bresnan, Broad, Steven Davies, Kieswetter, Morgan, Sidebottom, Swann, Luke Wright [ Images ], Yardy.
One-day squad: Strauss, Anderson, Bopara, Bresnan, Broad, Collingwood, Steven Davies, Morgan, Shahzad, Sidebottom, Swann, Trott, Luke Wright, Yardy.