Chaminda Vaas, with figures of three for 21, ripped apart the Chennai Super Kings' top-order to help the Deccan Chargers to a 31-run win.
The veteran Sri Lankan was named man of the match for his splendid bowling.
Vaas dismissed Murali Vijay (3) and Suresh Raina (6) in his second over in the space of four balls and got rid of dangerous Matthew Hayden (17) with his third.
Vaas, who had also picked two scalps in Deccan Chargers' opening match against the Kolkata Knight Riders on Friday, cleaned up Vijay to begin his charge.
Raina hit the second ball he faced for a massive six but Vaas had his revenge in the very next ball, inducing an edge off the left-hander's blade.
Australia's Hayden, winner of the Orange Cap last season, hit a six each of Rohit Sharma and RP Singh before Vaas returned to have him caught by RP at short fine.
Chennai had lost three wickets within the first five overs.
And they failed to recover from that early slump, losing eventually by 31 runs.
The Sri Lankan veteran, who announced his retirement from Test cricket to prolong his one-day and T20 career, again justified that decision of his.
In two matches in this edition, Vaas already has five scalps in his kitty.