It was Gasquet's third career title, following his triumph at the Nottingham Open in the run-up to Wimbledon where he was beaten by world number one Roger Federer in the first round.
Gasquet had to contend with some impressive serving from the hard-hitting Lopez but was frequently able to outplay and outrun his opponent with a clever variety of shots.
In the second set the Frenchman dropped just two points on his own serve while taking Lopez to deuce four times.
He failed to convert two break point chances, however, and paid the price when Lopez rallied to take the tiebreak.
There were no such mistakes in the following sets, as Gasquet's patient play was finally rewarded with three breaks of the Spaniard's serve.
"I think patience was the key today," said Gasquet, who watched Lopez fire a total of 24 aces past him.
"I had to wait for my opportunities because Feliciano was really putting me under pressure with his serving."
A former world number 12, who has since slipped to 60th following recent stomach and elbow injuries, Gasquet appeared to be back to his promising best on Sunday.
His latest tournament win marked his first success on clay, with both his previous title victories having come on the Nottingham grass courts.
"I am sure that I am playing better now than when I reached the number 12 spot," Gasquet added.
"The fact that I have now won on clay and grass is very important for my confidence because I want to show that I can play well on all surfaces."
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