The 37-year-old hit his sixth IPL fifty to help his side reach a formidable 181 for three in their stipulated 20 overs.
Ganguly's 46-ball 56 was inclusive of eight fours and one six and he also put on 94 runs for the opening wicket with Chris Gayle [ Images ] (40 from 21 balls) which laid the foundation for the win.
He helped the Knight Riders get to the 100-run mark by the 11th over - the fastest the team had reached the mark.
However, Vettori, having smashed for 15 by Dada in his first over came back and atoned, dismissing Ganguly with a nicely looped delivery to rattle the latter's stumps.
He also ran out his opposite number, Gautam Gambhir [ Images ] (47) at a crucial stage when Delhi seemed to be cruising, and took an important catch.
Ganguly was named the man-of-the-match for his efforts.