Australian batsman Mike Hussey and fast bowler Doug Bollinger have been withdrawn from Sunday's third and final ODI against India at Margao, and will fly home on Thursday.
According to the Daily Telegraph, Australian selectors want Hussey to be involved in a Sheffield Shield match for Western Australia next week, while Bollinger is still struggling to overcome his stomach muscle strain.
Bollinger's injury was initially thought to be a niggle, but it is clearly becoming a major concern ahead of next month's Ashes.
Bollinger did not play in Australia's five-wicket loss to Mahendra Singh Dhoni's men in Visakhapatnam on Wednesday.
"Bollinger reported some minor abdomen discomfort in an area unrelated to the original injury that ruled him out of the second Test and second ODI of the tour," Cricket Australia said in a statement.
"We do not think the new issue is serious however it will prevent him from achieving the workloads necessary for him to be available for selection in the third one-day match in Goa," added CA physiotherapist Kevin Sims.
It is believed that Australian selectors want Hussey to have a couple of dominant performances in the Sheffield Shield to ensure a Test place for the Ashes.
National Selection Panel Chairman Andrew Hilditch said, "As part of the ongoing individual work load management ahead of a an exciting Australian Summer and the ICC Cricket World
Cup in the subcontinent, Mike Hussey will not play in the third one-day game in India and will return home to Australia."
Earlier, on Wednesday, India defeated Australia at Visakhapatnam to take a 1-0 lead in the three-match ODI series.
Chasing 290 for victory, India scored 292 for five with seven balls to spare.
The first match at Kochi was called off due to rain.